A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics.
bioRxiv.
2023 Mar 13;. doi: 10.1101/2023.03.11.532245. PubMed PMID:
36993763; PubMed Central PMCID:
PMC10054961.
Regulation of DNA damage response by trimeric G-proteins.
iScience.
2023 Feb 17;26(2):105973. doi: 10.1016/j.isci.2023.105973. eCollection 2023 Feb 17. PubMed PMID:
36756378; PubMed Central PMCID:
PMC9900518.
A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding.
J Biol Chem.
2021 Jan-Jun;296:100493. doi: 10.1016/j.jbc.2021.100493. Epub 2021 Mar 3. PubMed PMID:
33675748; PubMed Central PMCID:
PMC8042451.
E-cigarettes compromise the gut barrier and trigger inflammation.
iScience.
2021 Feb 19;24(2):102035. doi: 10.1016/j.isci.2021.102035. eCollection 2021 Feb 19. PubMed PMID:
33537654; PubMed Central PMCID:
PMC7841355.
Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions.
iScience.
2020 Feb 21;23(2):100859. doi: 10.1016/j.isci.2020.100859. Epub 2020 Jan 22. PubMed PMID:
32058970; PubMed Central PMCID:
PMC7005484.
DAPLE protein inhibits nucleotide exchange on Gα(s) and Gα(q) via the same motif that activates Gαi.
J Biol Chem.
2020 Feb 21;295(8):2270-2284. doi: 10.1074/jbc.RA119.011648. Epub 2020 Jan 16. PubMed PMID:
31949046; PubMed Central PMCID:
PMC7039542.
Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors.
Sci Rep.
2019 Aug 20;9(1):12124. doi: 10.1038/s41598-019-48420-w. PubMed PMID:
31431650; PubMed Central PMCID:
PMC6702192.
Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.
Sci Rep.
2018 Dec 21;8(1):18036. doi: 10.1038/s41598-018-36173-x. PubMed PMID:
30575751; PubMed Central PMCID:
PMC6303298.
Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.
Sci Signal.
2018 Feb 27;11(519). doi: 10.1126/scisignal.aao4220. PubMed PMID:
29487190; PubMed Central PMCID:
PMC5862031.
A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.
Mol Biol Cell.
2017 Dec 1;28(25):3709-3723. doi: 10.1091/mbc.E17-06-0405. Epub 2017 Oct 11. PubMed PMID:
29021338; PubMed Central PMCID:
PMC5706997.
RNA methylation regulates hematopoietic stem and progenitor cell development.
J Genet Genomics.
2017 Oct 20;44(10):473-474. doi: 10.1016/j.jgg.2017.09.004. Epub 2017 Sep 21. PubMed PMID:
29037987.
Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.
Curr Protoc Chem Biol.
2016 Dec 7;8(4):265-298. doi: 10.1002/cpch.13. PubMed PMID:
27925669; PubMed Central PMCID:
PMC5154557.
GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Proc Natl Acad Sci U S A.
2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. PubMed PMID:
27621449; PubMed Central PMCID:
PMC5047194.
A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure.
J Genet Genomics.
2016 May 20;43(5):307-18. doi: 10.1016/j.jgg.2016.03.007. Epub 2016 Apr 2. PubMed PMID:
27216296.
RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1.
Blood.
2015 Aug 13;126(7):880-90. doi: 10.1182/blood-2015-01-622522. Epub 2015 Jun 24. PubMed PMID:
26109203.
Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
Mol Biol Cell.
2014 Nov 5;25(22):3654-71. doi: 10.1091/mbc.E14-05-0978. Epub 2014 Sep 3. PubMed PMID:
25187647; PubMed Central PMCID:
PMC4230624.
Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19.
Cell Death Dis.
2014 Jul 24;5(7):e1352. doi: 10.1038/cddis.2014.318. PubMed PMID:
25058426; PubMed Central PMCID:
PMC4123107.
Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1.
Small.
2013 May 27;9(9-10):1776-85. doi: 10.1002/smll.201202128. Epub 2012 Nov 23. PubMed PMID:
23180726; PubMed Central PMCID:
PMC4034474.
Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.
Structure.
2011 Dec 7;19(12):1826-36. doi: 10.1016/j.str.2011.09.018. PubMed PMID:
22153505; PubMed Central PMCID:
PMC3240820.
Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
Sci Signal.
2011 Sep 27;4(192):ra64. doi: 10.1126/scisignal.2002049. PubMed PMID:
21954290; PubMed Central PMCID:
PMC4226136.
The molecular basis of the Caskin1 and Mint1 interaction with CASK.
J Mol Biol.
2011 Sep 9;412(1):3-13. doi: 10.1016/j.jmb.2011.07.005. Epub 2011 Jul 12. PubMed PMID:
21763699; PubMed Central PMCID:
PMC3158819.
A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.
Mol Biol Cell.
2011 Mar 1;22(5):673-86. doi: 10.1091/mbc.E10-08-0738. Epub 2011 Jan 5. PubMed PMID:
21209316; PubMed Central PMCID:
PMC3046063.
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
FASEB J.
2011 Feb;25(2):590-9. doi: 10.1096/fj.10-167304. Epub 2010 Oct 25. PubMed PMID:
20974669; PubMed Central PMCID:
PMC3023389.
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.
Mol Biol Cell.
2010 Jul 1;21(13):2338-54. doi: 10.1091/mbc.e10-01-0028. Epub 2010 May 12. PubMed PMID:
20462955; PubMed Central PMCID:
PMC2893996.
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
J Biol Chem.
2010 Apr 23;285(17):12765-77. doi: 10.1074/jbc.M109.045161. Epub 2010 Feb 15. PubMed PMID:
20157114; PubMed Central PMCID:
PMC2857069.
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