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Leite APO, Li XC, Hassan R, Zheng X, Alexander B, Casarini DE, Zhuo JL. Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney. Clin Sci (Lond). 2021 Aug 13;135(15):1825-1843. doi: 10.1042/CS20201574. PubMed PMID: 34282828; PubMed Central PMCID: PMC8969897.
Li XC, Wang CH, Leite APO, Zhuo JL. Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT(1) (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury. Front Physiol. 2021;12:702797. doi: 10.3389/fphys.2021.702797. eCollection 2021. Review. PubMed PMID: 34408663; PubMed Central PMCID: PMC8364949.
Zhuo JL, Soleimani M, Li XC. New Insights into the Critical Importance of Intratubular Na(+)/H(+) Exchanger 3 and Its Potential Therapeutic Implications in Hypertension. Curr Hypertens Rep. 2021 Jun 10;23(6):34. doi: 10.1007/s11906-021-01152-7. Review. PubMed PMID: 34110521; PubMed Central PMCID: PMC8314783.
Li XC, Leite APO, Zheng X, Zhao C, Chen X, Zhang L, Zhou X, Rubera I, Tauc M, Zhuo JL. Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT-Agtr1a(-/-) Mice. Hypertension. 2021 Apr;77(4):1285-1298. doi: 10.1161/HYPERTENSIONAHA.120.16336. Epub 2021 Mar 1. PubMed PMID: 33641366; PubMed Central PMCID: PMC7946728.
Li XC, Zhou X, Zhuo JL. Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules: Novel Roles of Mitochondrial Ang II/AT(1a)/O(2)(-) and Ang II/AT(2)/NO Signaling. Hypertension. 2020 Jul;76(1):121-132. doi: 10.1161/HYPERTENSIONAHA.119.13942. Epub 2020 Jun 1. PubMed PMID: 32475319; PubMed Central PMCID: PMC7299167.
Li XC, Zhu D, Chen X, Zheng X, Zhao C, Zhang J, Soleimani M, Rubera I, Tauc M, Zhou X, Zhuo JL. Proximal Tubule-Specific Deletion of the NHE3 (Na(+)/H(+) Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice. Hypertension. 2019 Sep;74(3):526-535. doi: 10.1161/HYPERTENSIONAHA.119.13094. Epub 2019 Jul 29. PubMed PMID: 31352824; PubMed Central PMCID: PMC6685743.
Zhuo JL, Li XC. Angiotensin III/AT(2) Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension. J Am Heart Assoc. 2019 May 7;8(9):e012644. doi: 10.1161/JAHA.119.012644. PubMed PMID: 31039655; PubMed Central PMCID: PMC6512110.
Li XC, Zheng X, Chen X, Zhao C, Zhu D, Zhang J, Zhuo JL. Genetic and genomic evidence for an important role of the Na(+)/H(+) exchanger 3 in blood pressure regulation and angiotensin II-induced hypertension. Physiol Genomics. 2019 Apr 1;51(4):97-108. doi: 10.1152/physiolgenomics.00122.2018. Epub 2019 Mar 8. Review. PubMed PMID: 30849009; PubMed Central PMCID: PMC6485378.
Li XC, Soleimani M, Zhu D, Rubera I, Tauc M, Zheng X, Zhang J, Chen X, Zhuo JL. Proximal Tubule-Specific Deletion of the NHE3 (Na(+)/H(+) Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice. Hypertension. 2018 Dec;72(6):1328-1336. doi: 10.1161/HYPERTENSIONAHA.118.10884. PubMed PMID: 30571224; PubMed Central PMCID: PMC6309803.
Zhuo JL, Li XC. De Novo DNA (de)Methylation in the Kidney. Hypertension. 2018 Nov;72(5):1084-1086. doi: 10.1161/HYPERTENSIONAHA.118.11755. PubMed PMID: 30354833; PubMed Central PMCID: PMC6276805.
Li XC, Zhu D, Zheng X, Zhang J, Zhuo JL. Intratubular and intracellular renin-angiotensin system in the kidney: a unifying perspective in blood pressure control. Clin Sci (Lond). 2018 Jul 16;132(13):1383-1401. doi: 10.1042/CS20180121. Print 2018 Jul 16. Review. PubMed PMID: 29986878; PubMed Central PMCID: PMC6383523.
Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017 Nov;125(Pt A):21-38. doi: 10.1016/j.phrs.2017.06.005. Epub 2017 Jun 12. Review. PubMed PMID: 28619367; PubMed Central PMCID: PMC5607101.
Ferrão FM, Cardoso LHD, Drummond HA, Li XC, Zhuo JL, Gomes DS, Lara LS, Vieyra A, Lowe J. Luminal ANG II is internalized as a complex with AT(1)R/AT(2)R heterodimers to target endoplasmic reticulum in LLC-PK(1) cells. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F440-F449. doi: 10.1152/ajprenal.00261.2016. Epub 2017 May 3. PubMed PMID: 28468964; PubMed Central PMCID: PMC5582892.
Li XC, Zhuo JL. Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension. Curr Hypertens Rep. 2016 Aug;18(8):63. doi: 10.1007/s11906-016-0668-z. Review. PubMed PMID: 27372447; PubMed Central PMCID: PMC5578446.
Zhuo JL, Kobori H, Li XC, Satou R, Katsurada A, Navar LG. Augmentation of angiotensinogen expression in the proximal tubule by intracellular angiotensin II via AT1a/MAPK/NF-кB signaling pathways. Am J Physiol Renal Physiol. 2016 May 1;310(10):F1103-12. doi: 10.1152/ajprenal.00350.2015. Epub 2016 Feb 10. PubMed PMID: 26864937; PubMed Central PMCID: PMC4889322.
Li XC, Shull GE, Miguel-Qin E, Chen F, Zhuo JL. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines. Physiol Rep. 2015 Nov;3(11). doi: 10.14814/phy2.12605. PubMed PMID: 26564064; PubMed Central PMCID: PMC4673635.
Li XC, Shull GE, Miguel-Qin E, Zhuo JL. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. Physiol Genomics. 2015 Oct;47(10):479-87. doi: 10.1152/physiolgenomics.00056.2015. Epub 2015 Aug 4. PubMed PMID: 26242933; PubMed Central PMCID: PMC4593829.
Li XC, Gu V, Miguel-Qin E, Zhuo JL. Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney. Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F949-61. doi: 10.1152/ajprenal.00199.2014. Epub 2014 Aug 27. PubMed PMID: 25164083; PubMed Central PMCID: PMC4200294.
Li XC, Zhuo JL. Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin. Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F222-33. doi: 10.1152/ajprenal.00693.2013. Epub 2014 Apr 16. PubMed PMID: 24740791; PubMed Central PMCID: PMC4101628.
Zhuo JL, Ferrao FM, Zheng Y, Li XC. New frontiers in the intrarenal Renin-Angiotensin system: a critical review of classical and new paradigms. Front Endocrinol (Lausanne). 2013;4:166. doi: 10.3389/fendo.2013.00166. eCollection 2013. Review. PubMed PMID: 24273531; PubMed Central PMCID: PMC3822323.
Li XC, Zhuo JL. Current insights and new perspectives on the roles of hyperglucagonemia in non-insulin-dependent type 2 diabetes. Curr Hypertens Rep. 2013 Oct;15(5):522-30. doi: 10.1007/s11906-013-0383-y. Review. PubMed PMID: 23996678; PubMed Central PMCID: PMC3810031.
Zhuo JL, Li XC. Proximal nephron. Compr Physiol. 2013 Jul;3(3):1079-123. doi: 10.1002/cphy.c110061. Review. PubMed PMID: 23897681; PubMed Central PMCID: PMC3760239.
Li XC, Zhuo JL. Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15;304(8):R588-98. doi: 10.1152/ajpregu.00338.2012. Epub 2013 Feb 20. PubMed PMID: 23427083; PubMed Central PMCID: PMC3627953.
Li XC, Shao Y, Zhuo JL. AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice. Am J Physiol Renal Physiol. 2012 Sep;303(5):F746-56. doi: 10.1152/ajprenal.00644.2011. Epub 2012 Jun 27. PubMed PMID: 22739536; PubMed Central PMCID: PMC3468498.
Ellis B, Li XC, Miguel-Qin E, Gu V, Zhuo JL. Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R494-509. doi: 10.1152/ajpregu.00487.2011. Epub 2011 Dec 14. Review. PubMed PMID: 22170616; PubMed Central PMCID: PMC3833928.
Li XC, Zhuo JL. Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats. Kidney Int. 2011 Sep;80(6):620-32. doi: 10.1038/ki.2011.161. Epub 2011 Jun 22. PubMed PMID: 21697807; PubMed Central PMCID: PMC3164930.
Zhuo JL, Li XC. New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II. Peptides. 2011 Jul;32(7):1551-65. doi: 10.1016/j.peptides.2011.05.012. Epub 2011 Jun 14. Review. PubMed PMID: 21699940; PubMed Central PMCID: PMC3137727.
Li XC, Cook JL, Rubera I, Tauc M, Zhang F, Zhuo JL. Intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increases blood pressure in rats and mice. Am J Physiol Renal Physiol. 2011 May;300(5):F1076-88. doi: 10.1152/ajprenal.00329.2010. Epub 2011 Feb 9. PubMed PMID: 21307128; PubMed Central PMCID: PMC3094051.
Ohishi M, Dusting GJ, Fennessy PA, Mendelsohn FA, Li XC, Zhuo JL. Increased expression and co-localization of ACE, angiotensin II AT(1) receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries. Int J Physiol Pathophysiol Pharmacol. 2010 Apr 30;2(2):111-24. PubMed PMID: 21179388; PubMed Central PMCID: PMC3004229.
Li XC, Hopfer U, Zhuo JL. AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1342-52. doi: 10.1152/ajprenal.90734.2008. Epub 2009 Sep 2. PubMed PMID: 19726542; PubMed Central PMCID: PMC2781332.
Li XC, Shao Y, Zhuo JL. AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney Int. 2009 Jul;76(2):169-77. doi: 10.1038/ki.2009.134. Epub 2009 Apr 22. PubMed PMID: 19387470; PubMed Central PMCID: PMC2760268.
Li XC, Liao TD, Zhuo JL. Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice. Clin Sci (Lond). 2008 May;114(9):591-601. doi: 10.1042/CS20070257. PubMed PMID: 18028036; PubMed Central PMCID: PMC2773708.
Li XC, Zhuo JL. Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Cell Physiol. 2008 Apr;294(4):C1034-45. doi: 10.1152/ajpcell.00432.2007. Epub 2008 Feb 6. PubMed PMID: 18256274; PubMed Central PMCID: PMC2410035.
Li XC, Zhuo JL. In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice. Am J Physiol Renal Physiol. 2008 Feb;294(2):F293-302. doi: 10.1152/ajprenal.00398.2007. Epub 2007 Nov 28. PubMed PMID: 18045833; PubMed Central PMCID: PMC2277523.
Li XC, Zhuo JL. Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens. 2008 Jan;17(1):37-43. doi: 10.1097/MNH.0b013e3282f2903c. Review. PubMed PMID: 18090668; PubMed Central PMCID: PMC2278240.
Li XC, Zhuo JL. Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise. Clin Sci (Lond). 2007 Aug;113(4):183-93. doi: 10.1042/CS20070040. Review. PubMed PMID: 17623014; PubMed Central PMCID: PMC2277524.
Li XC, Navar LG, Shao Y, Zhuo JL. Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice. Am J Physiol Renal Physiol. 2007 Aug;293(2):F586-93. doi: 10.1152/ajprenal.00489.2006. Epub 2007 May 30. PubMed PMID: 17537986; PubMed Central PMCID: PMC2277521.
Li XC, Karadsheh MS, Jenkins PM, Brooks JC, Drapeau JA, Shah MS, Lautner MA, Stitzel JA. Chromosomal loci that influence oral nicotine consumption in C57BL/6J x C3H/HeJ F2 intercross mice. Genes Brain Behav. 2007 Jul;6(5):401-10. doi: 10.1111/j.1601-183X.2006.00266.x. Epub 2006 Sep 8. PubMed PMID: 17010155.
Li XC, Zhuo JL. Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells. Am J Physiol Cell Physiol. 2007 Jul;293(1):C367-78. doi: 10.1152/ajpcell.00463.2006. Epub 2007 Apr 11. PubMed PMID: 17428839; PubMed Central PMCID: PMC2277517.
Zhuo JL, Li XC. Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells. J Renin Angiotensin Aldosterone Syst. 2007 Mar;8(1):23-33. doi: 10.3317/jraas.2007.003. Review. PubMed PMID: 17487823; PubMed Central PMCID: PMC2276849.
Zhuo JL, Carretero OA, Peng H, Li XC, Regoli D, Neugebauer W, Rhaleb NE. Characterization and localization of Ac-SDKP receptor binding sites using 125I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H984-93. doi: 10.1152/ajpheart.00776.2006. Epub 2006 Oct 6. PubMed PMID: 17028162; PubMed Central PMCID: PMC2276842.
Zhuo JL, Carretero OA, Li XC. Effects of AT1 receptor-mediated endocytosis of extracellular Ang II on activation of nuclear factor-kappa B in proximal tubule cells. Ann N Y Acad Sci. 2006 Dec;1091:336-45. doi: 10.1196/annals.1378.078. PubMed PMID: 17341626; PubMed Central PMCID: PMC2276840.
Li XC, Carretero OA, Navar LG, Zhuo JL. AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases. Am J Physiol Renal Physiol. 2006 Aug;291(2):F375-83. doi: 10.1152/ajprenal.00405.2005. Epub 2006 Feb 14. PubMed PMID: 16478976; PubMed Central PMCID: PMC2276851.
Li XC, Carretero OA, Zhuo JL. Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells. Biochem Pharmacol. 2006 Jun 14;71(12):1711-9. doi: 10.1016/j.bcp.2006.03.018. Epub 2006 Mar 28. PubMed PMID: 16643859; PubMed Central PMCID: PMC2276839.
Zhuo JL, Li XC, Garvin JL, Navar LG, Carretero OA. Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1382-90. doi: 10.1152/ajprenal.00269.2005. Epub 2005 Dec 27. PubMed PMID: 16380461; PubMed Central PMCID: PMC2276850.
Li XC, Campbell DJ, Ohishi M, Yuan S, Zhuo JL. AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1024-33. doi: 10.1152/ajprenal.00221.2005. Epub 2005 Dec 27. PubMed PMID: 16380463; PubMed Central PMCID: PMC2276856.
Li XC, Carretero OA, Shao Y, Zhuo JL. Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C. Hypertension. 2006 Mar;47(3):580-5. doi: 10.1161/01.HYP.0000197946.81754.0a. Epub 2006 Jan 3. PubMed PMID: 16391176; PubMed Central PMCID: PMC2367309.
Li XC, Karadsheh MS, Jenkins PM, Stitzel JA. Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6JxC3H/HeJ F2 intercross mice. Behav Brain Res. 2005 Feb 10;157(1):79-90. doi: 10.1016/j.bbr.2004.06.010. PubMed PMID: 15617774.
Li XC, Widdop RE. AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR. Br J Pharmacol. 2004 Jul;142(5):821-30. doi: 10.1038/sj.bjp.0705838. Epub 2004 Jun 14. PubMed PMID: 15197103; PubMed Central PMCID: PMC1575063.
Rey FE, Li XC, Carretero OA, Garvin JL, Pagano PJ. Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91(phox). Circulation. 2002 Nov 5;106(19):2497-502. doi: 10.1161/01.cir.0000038108.71560.70. PubMed PMID: 12417549.
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