Lloyd Trotman
Professor
Cancer Center Deputy Director of Education
Ph.D., University of Zurich, 2001
trotman@cshl.edu | 516-367-5054
We pioneered generation of a unique genetic mouse model for therapy and analysis of metastatic prostate cancer. Recently, we developed 3-dimensional whole organ imaging technology that allows us to visualize cancer and metastatic progression in its native environment and at single cell resolution. Now, we use this platform to understand the role of nerves in tumor metastasis, and to develop novel therapeutic interventions against lethal disease.
Understanding Metastasis–Designing models of lethal cancer
The Trotman lab have developed the RapidCaP model system to study metastatic prostate cancer in vivo. This approach allows them to visualize and probe metastasis biology in the fully native and immune competent setting. They combine this with 3D whole organ imaging at single cell resolution to define the stepwise progression from primary tumor escape to colonization of metastatic sites such as bone, liver and lung.
The Neuro-Metastasis Interface
A major challenge in metastasis research is the identification of factors that control progression of non life-threatening tumors to lethal metastatic disease. In spite of much knowledge on the role of tumor neuron interactions in primary prostate cancer, the role of neurons in metastatic prostate cancer remains to be defined. They use their whole organ imaging platform on metastatic tumors to map and manipulate interactions between the peripheral nervous system and metastatic lesions in collaboration with neuroscientists at CSHL.
Therapy of Lethal Prostate Cancer
They use the RapidCaP model to understand evolution of metastasis and therapy resistance in order to advance the 70 year old standard of care, anti-hormonal therapy, which is not curative. They combine three cutting edge approaches to test novel therapeutic concepts, in vivo: Single cell analysis of metastatic therapy resistance, dietary control of prostate cancer progression, discovery of therapeutic targets in genome wide screens.
2022 Member, AACR Science Education and Career Advancement Committee
2021 Editorial Board member, The Journal of Cell Biology, Rockefeller Press, NY
2020 Editorial Advisory Board member, The EMBO Journal
2014 Pershing Square Sohn Prize
2014 American Cancer Society Scholar
2008 V Foundation Scholar
2007 Rita Allen Foundation Scholar
2006 ASCB Merton R. Bernfield Memorial Award
Bite into this diet and disease quiz
July 5, 2023
Test your knowledge of how diet and nutrition affect health and disease with this short quiz.
Cancer has a lot of nerve
August 22, 2022
Tumors recruit the nervous system to help them spread. Scientists are looking for ways to stop it.
The prostate cancer cell that got away
November 16, 2021
Like finding a needle in a haystack, CSHL scientists can now track prostate cancer in mice from its single cell start and as it spreads.
CSHL Ph.D. program: Graduating class of 2021
August 22, 2021
The CSHL School of Biological Sciences awarded Ph.D. degrees to seven students this year, who describe some of their experiences.
CSHL Association holds its annual meeting
January 29, 2021
The Cold Spring Harbor Laboratory Association welcomes four new directors and thanks three retiring ones.
Cold Spring Harbor Laboratory: Science is hope
December 21, 2020
The Laboratory is a leading research center for genetics, cancer, plant biology, quantitative biology, and neuroscience.
A science career path: Jason Williams
April 24, 2020
He is now a leader at the DNA Learning Center, the place that taught him to love biology in high school.
Congressman Suozzi honors Regeneron scholars at CSHL
February 26, 2020
Congressman Tom Suozzi congratulated Regeneron semi-finalists, including two Partners for the Future, at a ceremony hosted at CSHL.
Fresh insights into prostate cancer surprise Movember crowd
November 22, 2019
For a special “Movember” edition of Cocktails and Chromosomes, Dr. Lloyd Trotman explained what his lab is doing to understand deadly prostate cancers.
Movember with Lloyd Trotman—A Cocktails and Chromosomes talk about prostate cancer
November 19, 2019
In this Movember edition of Cocktails & Chromosomes, learn how new concepts of cancer evolution could turn prostate cancer into a curable disease.
All Publications
Next Directions in the Neuroscience of Cancers Arising outside the CNS
4 Apr 2024 | Cancer Discovery | 14(4):669-673
Amit, Moran, Anastasaki, Corina, Dantzer, Robert, Demir, Ihsan, Deneen, Benjamin, Dixon, Karen, Egeblad, Mikala, Gibson, Erin, Hervey-Jumper, Shawn, Hondermarck, Hubert, Magnon, Claire, Monje, Michelle, Na'ara, Shorook, Pan, Yuan, Repasky, Elizabeth, Scheff, Nicole, Sloan, Erica, Talbot, Sebastien, Tracey, Kevin, Trotman, Lloyd, Valiente, Manuel, Van Aelst, Linda, Venkataramani, Varun, Venkatesh, Humsa, Vermeer, Paola, Winkler, Frank, Wong, Richard, Gutmann, David, Borniger, Jeremy
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
27 Feb 2024 | Cancer Cell | :S1535-6108(24)00048
Colucci, Manuel, Zumerle, Sara, Bressan, Silvia, Gianfanti, Federico, Troiani, Martina, Valdata, Aurora, D'Ambrosio, Mariantonietta, Pasquini, Emiliano, Varesi, Angelica, Cogo, Francesca, Mosole, Simone, Dongilli, Cristina, Desbats, Maria, Contu, Liliana, Revankdar, Ajinkya, Chen, Jingjing, Kalathur, Madhuri, Perciato, Maria, Basilotta, Rossella, Endre, Laczko, Schauer, Stefan, Othman, Alaa, Guccini, Ilaria, Saponaro, Miriam, Maraccani, Luisa, Bancaro, Nicolò, Lai, Ping, Liu, Lei, Pernigoni, Nicolò, Mele, Federico, Merler, Sara, Trotman, Lloyd, Guarda, Greta, Calì, Bianca, Montopoli, Monica, Alimonti, Andrea
FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer
2024 | Cancers | 16(1):60
M. Swamynathan, Manojit, Mathew, Grinu, Aziz, Andrei, Gordon, Chris, Hillowe, Andrew, Wang, Hehe, Jhaveri, Aashna, Kendall, Jude, Cox, Hilary, Giarrizzo, Michael, Azabdaftari, Gissou, Rizzo, Robert, Diermeier, Sarah, Ojima, Iwao, Bialkowska, Agnieszka, Kaczocha, Martin, Trotman, Lloyd
Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells
2023 | PLoS ONE | 18(10):e0292483
Hillowe, Andrew, Gordon, Chris, Wang, Liqun, Rizzo, Robert, Trotman, Lloyd, Ojima, Iwao, Bialkowska, Agnieszka, Kaczocha, Martin, Pizzo, Salvatore
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells
Aug 2023 | Nature Cancer | 4(8):1102-1121
Brina, Daniela, Ponzoni, Adele, Troiani, Martina, Calì, Bianca, Pasquini, Emiliano, Attanasio, Giuseppe, Mosole, Simone, Mirenda, Michela, D'Ambrosio, Mariantonietta, Colucci, Manuel, Guccini, Ilaria, Revandkar, Ajinkya, Alajati, Abdullah, Tebaldi, Toma, Donzel, Deborah, Lauria, Fabio, Parhizgari, Nahjme, Valdata, Aurora, Maddalena, Martino, Calcinotto, Arianna, Bolis, Marco, Rinaldi, Andrea, Barry, Simon, Rüschoff, Jan, Sabbadin, Marianna, Sumanasuriya, Semini, Crespo, Mateus, Sharp, Adam, Yuan, Wei, Grinu, Mathew, Boyle, Alexandra, Miller, Cynthia, Trotman, Lloyd, Delaleu, Nicolas, Fassan, Matteo, Moch, Holger, Viero, Gabriella, de Bono, Johann, Alimonti, Andrea
Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology
4 Apr 2023 | Analytical Chemistry | 95(13):5661-5670
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott
PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers
3 Dec 2022 | Molecular Oncology
Aakula, Anna, Isomursu, Aleksi, Rupp, Christian, Erickson, Andrew, Gupta, Nikhil, Kauko, Otto, Shah, Pragya, Padzik, Artur, Pokharel, Yuba, Kaur, Amanpreet, Li, Song-Ping, Trotman, Lloyd, Taimen, Pekka, Rannikko, Antti, Lammerding, Jan, Paatero, Ilkka, Mirtti, Tuomas, Ivaska, Johanna, Westermarck, Jukka
Internally-controlled and dynamic optical measures of functional tumor biology
31 May 2022 | bioRxiv
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott
Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases
16 Nov 2021 | Cell Reports | 37(7):110027
Taranda, Julian, Mathew, Grinu, Watrud, Kaitlin, El-Amine, Nour, Lee, Matthew, Elowsky, Corey, Bludova, Anastasiia, Escobar Avelar, Sintia, Nowak, Dawid, Wee, Tse-Luen, Wilkinson, John, Trotman, Lloyd, Osten, Pavel
Advances in preclinical evaluation of experimental antibody-drug conjugates
4 Jul 2021 | Cancer Drug Resistance | 4:745-754
Lyons, Scott, Plenker, Dennis, Trotman, Lloyd