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Page 1
Building access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects.
Kanter J, Smith WR, Desai PC, Treadwell M, Andemariam B, Little J, Nugent D, Claster S, Manwani DG, Baker J, Strouse JJ, Osunkwo I, Stewart RW, King A, Shook LM, Roberts JD, Lanzkron S. Kanter J, et al. Among authors: little j. Blood Adv. 2020 Aug 25;4(16):3804-3813. doi: 10.1182/bloodadvances.2020001743. Blood Adv. 2020. PMID: 32785684 Free PMC article.
Iron overload in sickle cell disease.
Raghupathy R, Manwani D, Little JA. Raghupathy R, et al. Adv Hematol. 2010;2010:272940. doi: 10.1155/2010/272940. Epub 2010 May 17. Adv Hematol. 2010. PMID: 20490352 Free PMC article.
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity.
Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Onyekwere O, Castro OL, Sachdev V, Waclawiw MA, Woolson R, Goldsmith JC, Gladwin MT; walk-PHaSST Investigators and Patients. Machado RF, et al. Among authors: little ja. Blood. 2011 Jul 28;118(4):855-64. doi: 10.1182/blood-2010-09-306167. Epub 2011 Apr 28. Blood. 2011. PMID: 21527519 Free PMC article. Clinical Trial.
Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.
Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR; Walk-PHASST Investigators. Sachdev V, et al. Among authors: little ja. Circulation. 2011 Sep 27;124(13):1452-60. doi: 10.1161/CIRCULATIONAHA.111.032920. Epub 2011 Sep 6. Circulation. 2011. PMID: 21900080 Free PMC article. Clinical Trial.
Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients.
Breda L, Casu C, Gardenghi S, Bianchi N, Cartegni L, Narla M, Yazdanbakhsh K, Musso M, Manwani D, Little J, Gardner LB, Kleinert DA, Prus E, Fibach E, Grady RW, Giardina PJ, Gambari R, Rivella S. Breda L, et al. Among authors: little j. PLoS One. 2012;7(3):e32345. doi: 10.1371/journal.pone.0032345. Epub 2012 Mar 27. PLoS One. 2012. PMID: 22479321 Free PMC article.
The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.
Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Goldsmith JC, Gordeuk VR, Gladwin MT; Walk-PHASST Investigators and Patients. Nouraie M, et al. Among authors: little ja. Haematologica. 2013 Mar;98(3):464-72. doi: 10.3324/haematol.2012.068965. Epub 2012 Sep 14. Haematologica. 2013. PMID: 22983573 Free PMC article.
Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Goldsmith JC, Kato GJ, Gordeuk VR, Machado RF; walk-PHaSST Investigators and Patients. Gladwin MT, et al. Among authors: little ja. PLoS One. 2014 Jul 2;9(7):e99489. doi: 10.1371/journal.pone.0099489. eCollection 2014. PLoS One. 2014. PMID: 24988120 Free PMC article. Clinical Trial.
Increased acute care utilization in a prospective cohort of adults with sickle cell disease.
Lanzkron S, Little J, Field J, Shows JR, Wang H, Seufert R, Brooks J, Varadhan R, Haywood C Jr, Saheed M, Huang CY, Griffin B, Frymark S, Piehet A, Robertson D, Proudford M, Kincaid A, Green C, Burgess L, Wallace M, Segal J. Lanzkron S, et al. Among authors: little j. Blood Adv. 2018 Sep 25;2(18):2412-2417. doi: 10.1182/bloodadvances.2018018382. Blood Adv. 2018. PMID: 30254105 Free PMC article.
Advances in the Treatment of Sickle Cell Disease.
Kapoor S, Little JA, Pecker LH. Kapoor S, et al. Mayo Clin Proc. 2018 Dec;93(12):1810-1824. doi: 10.1016/j.mayocp.2018.08.001. Epub 2018 Nov 7. Mayo Clin Proc. 2018. PMID: 30414734 Review.
Emerging disease-modifying therapies for sickle cell disease.
Carden MA, Little J. Carden MA, et al. Among authors: little j. Haematologica. 2019 Sep;104(9):1710-1719. doi: 10.3324/haematol.2018.207357. Epub 2019 Aug 14. Haematologica. 2019. PMID: 31413089 Free PMC article. Review.
End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings.
Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, Krishnamurti L, Little J, Makani J, Malik P, McGann PT, Minniti C, Morris CR, Odame I, Oneal PA, Setse R, Sharma P, Shenoy S. Farrell AT, et al. Among authors: little j. Blood Adv. 2019 Dec 10;3(23):4002-4020. doi: 10.1182/bloodadvances.2019000883. Blood Adv. 2019. PMID: 31809537 Free PMC article.
Kneeling Was the First Step for Sickle Cell Disease.
Desai P, Little J, Kanter J, Bridges K, Andemariam B, Lanzkron S. Desai P, et al. Among authors: little j. Ann Intern Med. 2021 Jul;174(7):1004-1005. doi: 10.7326/M20-7418. Epub 2021 Mar 23. Ann Intern Med. 2021. PMID: 33750189 No abstract available.
Treatment of Acute Pain in Adults With Sickle Cell Disease in an Infusion Center Versus the Emergency Department : A Multicenter Prospective Cohort Study.
Lanzkron S, Little J, Wang H, Field JJ, Shows JR, Haywood C Jr, Saheed M, Proudford M, Robertson D, Kincaid A, Burgess L, Green C, Seufert R, Brooks J, Piehet A, Griffin B, Arnold N, Frymark S, Wallace M, Abu Al Hamayel N, Huang CY, Segal JB, Varadhan R. Lanzkron S, et al. Among authors: little j. Ann Intern Med. 2021 Sep;174(9):1207-1213. doi: 10.7326/M20-7171. Epub 2021 Jul 6. Ann Intern Med. 2021. PMID: 34224261
Gaps in the diagnosis and management of iron overload in sickle cell disease: a 'real-world' report from the GRNDaD registry.
Wilson SR, Sears M, Williams E, Drapekin J, Sivakumar I, Padrino S, Desai PC, Hager W, Manwani D, Clay LJ, Field JJ, Kanter J, Cohen AJ, Saif Ur Rehman S, Lanzkron S, Little JA; GRNDaD investigators. Wilson SR, et al. Among authors: little ja. Br J Haematol. 2021 Dec;195(5):e157-e160. doi: 10.1111/bjh.17762. Epub 2021 Aug 22. Br J Haematol. 2021. PMID: 34423416 No abstract available.
GRNDaD: big data and sickle cell disease.
Lanzkron S, Manwani D, Desai P, Kanter J, Little J. Lanzkron S, et al. Among authors: little j. Blood Adv. 2022 Feb 8;6(3):1088. doi: 10.1182/bloodadvances.2021005282. Blood Adv. 2022. PMID: 35133406 Free PMC article.
Sickle Cell Disease: New Approaches for an Old Disease.
Lanzkron S, Little J. Lanzkron S, et al. Among authors: little j. Hematol Oncol Clin North Am. 2022 Dec;36(6):xiii-xiv. doi: 10.1016/j.hoc.2022.09.001. Hematol Oncol Clin North Am. 2022. PMID: 36400546 No abstract available.
A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease.
Man Y, Kucukal E, Liu S, An R, Goreke U, Wulftange WJ, Sekyonda Z, Bode A, Little JA, Manwani D, Stavrou EX, Gurkan UA. Man Y, et al. Among authors: little ja. Biosens Bioelectron. 2023 Feb 15;222:114921. doi: 10.1016/j.bios.2022.114921. Epub 2022 Nov 24. Biosens Bioelectron. 2023. PMID: 36521205 Free PMC article.
Biopsychosocial Factors Associated With Pain and Pain-Related Outcomes in Adults and Children With Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multicenter Registry.
Kenney MO, Wilson S, Shah N, Bortsov A, Smith WR, Little J, Lanzkron S, Kanter J, Padrino S, Owusu-Ansah A, Cohen A, Desai P, Manwani D, Rehman SSU, Hagar W, Keefe F. Kenney MO, et al. Among authors: little j. J Pain. 2024 Jan;25(1):153-164. doi: 10.1016/j.jpain.2023.07.029. Epub 2023 Aug 5. J Pain. 2024. PMID: 37544393 Free article.
Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial.
Gladwin MT, Gordeuk VR, Desai PC, Minniti C, Novelli EM, Morris CR, Ataga KI, De Castro L, Curtis SA, El Rassi F, Ford HJ, Harrington T, Klings ES, Lanzkron S, Liles D, Little J, Nero A, Smith W, Taylor JG 6th, Baptiste A, Hagar W, Kanter J, Kinzie A, Martin T, Rafique A, Telen MJ, Lalama CM, Kato GJ, Abebe KZ. Gladwin MT, et al. Among authors: little j. Lancet Haematol. 2024 Mar 27:S2352-3026(24)00045-0. doi: 10.1016/S2352-3026(24)00045-0. Online ahead of print. Lancet Haematol. 2024. PMID: 38554715
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
Kato GJ, McGowan V, Machado RF, Little JA, Taylor J 6th, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM Jr, Gladwin MT. Kato GJ, et al. Among authors: little ja. Blood. 2006 Mar 15;107(6):2279-85. doi: 10.1182/blood-2005-06-2373. Epub 2005 Nov 15. Blood. 2006. PMID: 16291595 Free PMC article.
Genetic determinants of haemolysis in sickle cell anaemia.
Milton JN, Rooks H, Drasar E, McCabe EL, Baldwin CT, Melista E, Gordeuk VR, Nouraie M, Kato GR, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Rana S, Castro O, Zhang Y, Thein SL, Sebastiani P, Gladwin MT; Walk-PHAAST Investigators; Steinberg MH. Milton JN, et al. Br J Haematol. 2013 Apr;161(2):270-8. doi: 10.1111/bjh.12245. Epub 2013 Feb 14. Br J Haematol. 2013. PMID: 23406172 Free PMC article. Clinical Trial.
Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.
Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J. Drawz P, et al. Among authors: little j. Clin J Am Soc Nephrol. 2016 Feb 5;11(2):207-15. doi: 10.2215/CJN.03940415. Epub 2015 Dec 15. Clin J Am Soc Nephrol. 2016. PMID: 26672090 Free PMC article.
Exercise-induced changes of vital signs in adults with sickle cell disease.
Johnson S, Gordeuk VR, Machado R, Gibbs JSR, Hildesheim M, Little JA, Kato GJ, Gladwin MT, Nouraie M. Johnson S, et al. Among authors: little ja. Am J Hematol. 2021 Dec 1;96(12):1630-1638. doi: 10.1002/ajh.26369. Epub 2021 Oct 20. Am J Hematol. 2021. PMID: 34626431 Free PMC article. Clinical Trial.
3,195 results